KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (36 entries covering 21 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAPK14 (p38a)	MAPK	CMGC	1di9	A		4-[3-methylsulfanylanilino]-6,7-dimethoxyquinazoline	Human	5251	0.48
EGFR	EGFR	TK	4lrm	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	867	0.40
EGFR	EGFR	TK	4ll0	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	804	0.40
AURKA (AurA)	Aur	Other	2c6e	A		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	1989	0.41
EGFR	EGFR	TK	4hjo	A		[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	835	0.69
EGFR	EGFR	TK	4ll0	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	796	0.40
EGFR	EGFR	TK	4lrm	C		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	781	0.40
EGFR	EGFR	TK	1m17	A	B	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	905	0.69
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.44
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.44
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.44
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.44
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.44
EPHB4 (EphB4)	Eph	TK	2vwu	A		n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	Human	370	0.41
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.53
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.53
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.53
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.44
ABL1	Abl	TK	8ssn	A		6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine	Human	14878	0.44
CSNK2A1 (CK2a1)	CK2	CMGC	3pe2	A	B	5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid	Human	5519	0.40
CSNK2A1 (CK2a1)	CK2	CMGC	3pe2	A	A	5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid	Human	5508	0.40
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.44
EGFR	EGFR	TK	4lrm	D		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	786	0.40
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.44
EGFR	EGFR	TK	4lrm	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	901	0.40
EGFR	EGFR	TK	4lrm	E		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	825	0.40
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.44
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.44
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.44
AURKA (AurA)	Aur	Other	2c6e	B		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	2046	0.41
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.53
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.53
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.44
EGFR	EGFR	TK	1m17	A	A	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	873	0.69
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.53
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.53