| BTK | Tec | TK | 4yhf | A | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2916 | 0.40 | |
| BTK | Tec | TK | 7l5p | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14269 | 0.40 | |
| EGFR | EGFR | TK | 5j9y | A | A | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6946 | 0.44 | |
| EGFR | EGFR | TK | 5yu9 | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9428 | 0.55 | |
| EGFR | EGFR | TK | 5j9y | A | B | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6945 | 0.44 | |
| EGFR | EGFR | TK | 5yu9 | D | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9431 | 0.55 | |
| BTK | Tec | TK | 7l5o | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14272 | 0.40 | |
| BTK | Tec | TK | 7l5o | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14271 | 0.40 | |
| BTK | Tec | TK | 7l5o | A | C | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14268 | 0.40 | |
| BTK | Tec | TK | 7l5p | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14270 | 0.40 | |
| EGFR | EGFR | TK | 5yu9 | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9430 | 0.55 | |
| BTK | Tec | TK | 6omu | A | A | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11529 | 0.44 | |
| EGFR | EGFR | TK | 5yu9 | C | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9432 | 0.55 | |
| BTK | Tec | TK | 7r60 | A | A | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13937 | 0.40 | |
| BTK | Tec | TK | 4yhf | B | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2912 | 0.40 | |
| BTK | Tec | TK | 5p9i | A | C | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7638 | 0.55 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12678 | 0.45 | |
| MAP2K7 | STE7 | STE | 6ib0 | A | | 1-[(3~{r})-3-(4-azanyl-3-ethynyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one | Human | 10922 | 0.42 | |
| MAP2K7 | STE7 | STE | 6qg7 | A | | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 11083 | 0.44 | |
| EGFR | EGFR | TK | 5yu9 | C | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9427 | 0.55 | |
| EGFR | EGFR | TK | 5j9z | A | | (r)-1-(3-(4-amino-3-(1-methyl-1h-indol-3-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6947 | 0.43 | |
| BTK | Tec | TK | 5p9m | A | A | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7634 | 0.59 | |
| BTK | Tec | TK | 6omu | A | B | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11530 | 0.44 | |
| EGFR | EGFR | TK | 5yu9 | D | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9429 | 0.55 | |
| EGFR | EGFR | TK | 5yu9 | B | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9433 | 0.55 | |
| Btk (BTK) | Tec | TK | 8ff0 | A | | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Mouse | 14834 | 0.59 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12686 | 0.45 | |
| EGFR | EGFR | TK | 5yu9 | B | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9434 | 0.55 | |
| BTK | Tec | TK | 5p9j | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7628 | 0.45 | |
| BTK | Tec | TK | 5p9i | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7627 | 0.55 | |
| BTK | Tec | TK | 5p9m | A | B | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7639 | 0.59 | |
| BTK | Tec | TK | 4yhf | B | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2897 | 0.40 | |
| BTK | Tec | TK | 5p9j | A | C | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7640 | 0.45 | |
| BTK | Tec | TK | 7r60 | A | B | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13939 | 0.40 | |
| BTK | Tec | TK | 5p9j | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7637 | 0.45 | |
| BTK | Tec | TK | 5p9i | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7642 | 0.55 | |
| BTK | Tec | TK | 5p9m | A | C | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7641 | 0.59 | |
| BTK | Tec | TK | 4yhf | A | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2902 | 0.40 | |
Match: