KLIFS is a kinase database that dissects experimental structures of catalytic kinase domains and the way kinase inhibitors interact with them. The KLIFS structural alignment enables the comparison of all structures and ligands to each other. Moreover, the KLIFS residue numbering scheme capturing the catalytic cleft with 85 residues enables the comparison of the interaction patterns of kinase-inhibitors, for example, to identify crucial interactions determining kinase-inhibitor selectivity.
For more information, go through the frequently asked questions (FAQ) or read our articles in Nucleic Acids Research (2020), Trends in Pharmacological Sciences (2019), and ACS Journal of Medicinal Chemistry (2014).
|Structures (# PDBs)||6372|
|KLIFS users in Sep-2023||1607|
KLIFS @ RSC symposium on kinase inhibitor design01-May-2023
2023 - a sneak peek05-Jan-2023
KLIFS workshop @ May 19th02-Apr-2022